Increasing ‘local content’ in infrastructure procurement. Part 1

Bone Marrow Transplantation in Thalassemia (Part 1)

During the last two decades conventional therapy has improved the prognosis of thalassemia. However, despite such improvement it still remains a progressive disease with treatment-related complications such as hepatitis, liver fibrosis, and cardiac disease. Bone marrow transplantation (BMT) can prevent or delay progression of the aforementioned complications. The importance of clinical research...

Representations Part 1 — A Common Infrastructure for Benchmarks

A variety of logical frameworks support the use of higher-order abstract syntax (HOAS) in representing formal systems. Although these systems seem superficially the same, they differ in a variety of ways; for example, how they handle a context of assumptions and which theorems about a given formal system can be concisely expressed and proved. Our contributions in this paper are three-fold: 1) w...

Combinatorial Auctions in Procurement 1

Making the “right” pricing decision in sales or procurement is a complex task. While the types of pricing policies/methods used in the exchange of goods and services vary greatly, we can divide these mechanisms under two broad categories: posted price mechanisms and price discovery mechanisms. Under a posted price mechanism, a good is sold at a take-it-or-leave-it price determined by the seller...

Increasing the Content of High-Content Screening

Target-based high-throughput screening (HTS) has recently been critiqued for its relatively poor yield compared to phenotypic screening approaches. One type of phenotypic screening, image-based high-content screening (HCS), has been seen as particularly promising. In this article, we assess whether HCS is as high content as it can be. We analyze HCS publications and find that although the numbe...

Making Infrastructure Procurement Processes more Flexible under Uncertainty